Bone Drug Could Protect Stem Cells from Ageing

Bone Drug Could Protect Stem Cells from Ageing

Authored by DesiMD Doctor on 22 Dec 2015 - 11:54

The mechanism behind human ageing is, impairment of the structure and DNA damage, where stem cells lose their power to maintain and address the injured tissues in which they live.

A breakthrough study conducted at the University of Sheffield has revealed that a drug called zoledronate, which is currently used to treat osteoporosis, can protect stem cells from ageing. Stem cell is an undifferentiated cell of a multicellular organism which is capable of giving rise to indefinitely more cells of the same type, and from which certain other kinds of cell arise by differentiation.

"The drug enhances the repair of the damage in DNA occurring with age in stem cells in the bone. It is also likely to work in other stem cells too,” said Professor Ilaria Bellantuono, from the University's Department of Metabolism.

Researchers now want to know if the drug can detain or return the ageing in stem cells in senior citizens and the maintenance of tissues such as the heart, the muscle and immune cells, keeping them healthier for longer.

According to the researchers, nearly 50% of people aged above 75 years suffer from three or more disease simultaneously such as cardiovascular disease, infections, muscle weakness and osteoporosis. In the coming years, it is expected that this drug could be used to treat, forbid or delay the attack of such diseases instead of using a mixture of drugs.

Dr Bellantuono added: "We are hopeful that this research will pave the way for a better cure for cancer patients and keeping older people healthier for longer by reducing the risk of developing multiple age-related diseases."


Reference: Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects their Function, Juhi Misra, Sindhu T. Mohanty, Sanjeev Madan, James A. Fernandes, F. Hal Ebetino, R. Graham, G. Russell, Ilaria Bellantuono, Stem Cells, doi: 10.1002/stem.2255, published online 17 December 2015;  University of Sheffield

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