High Testosterone Levels May Increase Uterine Fibroid Risk : Study

High Testosterone Levels May Increase Uterine Fibroid Risk : Study

Authored by DesiMD Doctor on 19 Dec 2015 - 10:32


According to the latest study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism- women who have elevated testosterone and estrogen levels in midlife have a greater risk of developing uterine fibroids .

Study author, Jason Y.Y. Wong, Sc.D, at Stanford University School of Medicine and group said obese and overweight women are at a greater risk of developing uterine fibroids causing infertility, irregular bleeding, pelvic pain, recurrent pregnancy loss and other reproductive complications.

Researchers analyzed the hormone levels and the incidence of uterine fibroids in 3240 women in the Study of Women's Health around the Nation (SWAN), out of which only 43.6% completed the follow-up visits.

Study Findings: After a follow-up of 13 years, 512 women accounted for having a single incidence of fibroids, and other 478 women had continual cases. Women who had elevated testosterone levels in the blood were 1.33 times more liable to develop a single incidence of fibroids as compared with women who had low levels of testosterone. And women who had high levels of both testosterone and estrogen faced even greater risk. However, women with high levels of both hormones were less liable to have a reoccurrence of fibroids than women with low levels of the hormones.

"Our findings are particularly interesting because testosterone was previously unrecognized as a factor in the development of uterine fibroids. The research opens up new lines of inquiry regarding how fibroids develop and how they are treated. Given that managing uterine fibroids costs an estimated $34.4 billion in annual medical expenditures nationwide, it is important to identify new ways to better treat this common condition,” said another study author, Dr Jennifer S. Lee.


Reference: Endocrine Society's Journal of Clinical Endocrinology & Metabolism; The study, 'Circulating Sex Hormones and Risk of Uterine Fibroids: Study of Women's Health Across the Nation (SWAN) ' DOI:10.1210/jc.2015-2935



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