New Test Discovered for Early Diagnosis of Infectious Diseases

New Test Discovered for Early Diagnosis of Infectious Diseases

Authored by DesiMD Doctor on 24 Dec 2015 - 10:57


According to the latest study conducted at McMaster University (published in the German scientific journal Angewandte Chemie International Edition)-researchers have identified a new way of finding specific strains of deadly bacteria and track their trail of illness. Presumably, this will help control infectious diseases, as it can lead to timely care of patients and prevent potential outbreaks. Bacterial infections are a threat to public health and are responsible for many annual costly outbreaks.

Yingfu Li, principal investigator and professor of Biochemistry and Biomedical Sciences, Michael G. DeGroote School of Medicine said, "With this new technology we will be able to develop molecular tools to recognize any superbug down to the specific strain, and there will be many wide-ranging applications.”  

Discovery: Scientist have discovered a new way to make DNAzymes, or single-stranded DNA molecules with catalytic capabilities from a plain test tube method, that permits for isolation of rare DNA sequences with special functions.

Researchers examined a molecule that incisively distinguishes the strain which caused the 2011 Hamilton, Ont. irruption of Clostridium stubborn infection, which was very infectious and not susceptible to antibiotics, and also fatal for patients. The team can now promptly identify this superbug using their new molecular probe, rather than opting for few different tests to identify the bacterial strain.

Li says that this phase works for various other applications where we can analyze infectious disease. The best part is, when compared to the current tests which take two days for rapid diagnosis and treatment, this test can be done within an hour, much quicker and more accurate.

Bruno Salena, who co-authored the study said, "This technology can be extended to the further discovery of other superbug strain-specific pathogens. For example, such technology would prove useful in the identification of hypervirulent or resistant strains, implementation of the most appropriate strain-specific treatments and tracking of outbreaks.”

He adds, this technology is affordable and does not even need a lab. It can be adapted to also identify other diseases, beyond just bacteria and viruses.


Reference: ”A Catalytic DNA Activated by a Specific Strain of Bacterial Pathogen” Dr. Zhifa Shen, Dr. Zaisheng Wu, Dingran Chang, Wenqing Zhang, Dr. Kha Tram, Prof. Dr. Christine Lee, Prof. Dr. Peter Kim, Prof. Dr. Bruno J. Salena, Prof. Dr. Yingfu Li. Angewandte Chemie International Edition, DOI: 10.1002/ange.201510125. First published: 16 December 2015; McMaster University

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