Gut Bacteria: How They Regulate Weight Gain
Healthy Living

Gut Bacteria: How They Regulate Weight Gain

Authored by DesiMD Doctor on 16 May 2014 - 12:05

A team of researchers from the Ailmentary Pharmabiotic Centre in University College Cork have discovered how the gut bacteria and their host communicate and regulate weight gain and blood cholesterol levels.

The findings of the study, which are now published in the Proceedings of the National Academy of Sciences, USA, have revealed  how a particular bacterial protein, which reduces blood cholesterol levels and weight gain could be the major factor contributing to the success.

Led by Dr Cormac Gahan and Dr Susan Joyce, the team analyzed the bacterial protein (known as bile salt hydrolase, which is produced by gut bacteria) and understood how it modifies the bile acids in the gut thereby reducing cholesterol levels.

"Recent work by other groups has shown that bile acids act as signalling molecules in the host, almost like a hormonal network, with an ability to influence host metabolism. What we have done is to show that a specific mechanism exists by which bacteria in the gut can influence this process with significant consequences for the host," Dr Gahan explained.

"The findings may be used as a basis for the future selection of probiotics or dietary interventions which target this mechanism to regulate weight gain or high cholesterol. We now have the potential for matching probiotic strains with specific end-user needs. Work is underway to determine how this system operates in humans," Dr Joyce added.





*Disclaimer: This is not medical advice. The content is for educational purposes only. Please contact your doctor for any health care issues.